Application Note
Genetic Mapping of AAV9 for Empty/Truncated/Full Analysis
Successful gene therapy development manufacturing at scale is a matter of ensuring an optimal vector for the genetic material, as well as the integrity of this one, to guarantee the treatment effectiveness. In this Application Note, our team demonstrates how NanoMosaic’s platform allows researchers to obtain high throughputs and a high level of accuracy to characterize capsids and transgenes—all from a single instrument.
Tessie's Non-Exhaustive Benefits
- NanoMosaic Platform provides highly accurate sample characterization in 4 h with crude sample volume as low as ~2 µL for capsid and transgene assay.
- Tessie emerges as a new reliable solution for precisely quantifying multiple transgene forms. Unlike current methods such as ELISA and dPCR, which often suffer from broken workflows and provide only partial information, Tessie accurately discriminates full-length transgene forms from truncated ones.
- While AUC and CDMS can only provide qualitative assessments of Empty/Full/Partial ratios, the NanoMosaic system delivers quantitative assessments of full-length and partial species.
Complete the Form to Download the Application Note.
Application Note
Genetic Mapping of AAV9 for Empty/Truncated/Full Analysis
Successful gene therapy development manufacturing at scale is a matter of ensuring an optimal vector for the genetic material, as well as the integrity of this one, to guarantee the treatment effectiveness. In this Application Note, our team demonstrates how NanoMosaic’s platform allows researchers to obtain high throughputs and a high level of accuracy to characterize capsids and transgenes—all from a single instrument.
Tessie's Non-Exhaustive Benefits
- NanoMosaic Platform provides highly accurate sample characterization in 4 h with crude sample volume as low as ~2 µL for capsid and transgene assay.
- Tessie emerges as a new reliable solution for precisely quantifying multiple transgene forms. Unlike current methods such as ELISA and dPCR, which often suffer from broken workflows and provide only partial information, Tessie accurately discriminates full-length transgene forms from truncated ones.
- While AUC and CDMS can only provide qualitative assessments of Empty/Full/Partial ratios, the NanoMosaic system delivers quantitative assessments of full-length and partial species.
Complete the Form to Download the Application Note.