Case Study
Direct full-length transgene quantification provides the gold standard for gene therapy quality assessment
Highlights:
- DNA titer measurements of a known mixture of full-length, long partial, and short partial DNA fragments demonstrate the accuracy and molecular specificity of the nanoneedle technology.
- In typical preparations, ITR-adjacent titers are elevated due to end truncations, while central-region titers more closely reflect full-length genomes.
- The complete poster describes robust quantification and determination of AAV genome species packaged and capsid titers during manufacturing process.
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Case Study
Direct full-length transgene quantification provides the gold standard for gene therapy quality assessment
Highlights:
- DNA titer measurements of a known mixture of full-length, long partial, and short partial DNA fragments demonstrate the accuracy and molecular specificity of the nanoneedle technology.
- In typical preparations, ITR-adjacent titers are elevated due to end truncations, while central-region titers more closely reflect full-length genomes.
- The complete poster describes robust quantification and determination of AAV genome species packaged and capsid titers during manufacturing process.